However, the home side could have taken a point from the match had Danny Welbeck's late equaliser stood.
With Gareth Southgate taking great encouragement from his side's performances in Russian Federation, he kept faith with the core of his squad, despite suggesting he would bring in new faces this month. Obviously you've got to respect his decision. "A lot of these guys have had zero minutes in the league, but the right thing is to give them game time". At the moment we have a different profile of player, we can't play the way that they want to play.
England next face Switzerland in a friendly on Tuesday.
Florence becomes a hurricane, takes aim at US Southeast
There are no coastal watches or warnings in effect, but officials say it is expected to become a hurricane by Monday. Forecasters said it is now around 1,500 miles east of the Windward Islands and is carrying winds of 65mph (100kph).
England will be desperate to find attacking alternatives in the long term.
There must be something in the hotter climes and the siestas because Spain have created those kinds of players for fun over the last two decades while in England nobody can find one, despite the self-proclaimed most competitive top-flight in football.
Theo Walcott's hopes of a recall at the age of 29 also appear bleak and Southgate has admitted that Kane's workload is a worry.
Shaw set up Marcus Rashford's opener in the 11th minute but Spain scored twice in 20 minutes to secure the victory.
Packers’ Aaron Rodgers injured, leaves games on cart
The doc and I had a conversation in there. "After it was decided I was going to come back I knew it might give us a little jolt". And even though Rodgers played, he hobbled - much like he did when a calf injury slowed him down late in the 2014 season.
"I thought we played much better in the second half".
Southgate, whose team have lost three games in a row, added: "Clubs would be holding their breath and hiding behind their sofas watching our teams go out". 'Me and the defenders were challenging for the ball.
Should Switzerland continue to go with former Newcastle United full back Mbabu, who won his first senior cap against Iceland in the 6-0 win, then it will fall on Rose to take full advantage.
With the likes of Andres Iniesta, David Silva and Gerard Pique all retiring from the global stage, Luis Enrique's starting lineup had only five players who started against Russian Federation in the World Cup last-16 penalty shootout loss.
Hurricane Florence causing 85-mph winds, will become major hurricane Monday
Hurricane Helene is expected to turn north into the middle of the Atlantic Ocean, according to the National Hurricane Center . A forecast from the hurricane center projected that Florence will pick up speed in the coming days.
A near capacity 90,000 crowd at Wembley came to show their appreciation of England's run to the semi-finals in Russian Federation for the first time in 28 years. "That focus will come on me and I'm not concerned about it".