Djokovic leads 6-4 3-6 7-6 (9) after saving three set points in the tiebreaker.
"Just playing like that in those conditions, it was really tough for both of us".
Friday proved to be another long day for Anderson, who said after the match that he hoped the 50-game fifth set would be "a sign for Grand Slams to change".
"So do I. I think it will be just like the last final; it will be a really good final". South African-born Kevin Curren contested the 1985 final but he had become a USA citizen by then.
Isner, 33, will be playing in his first major semi-final and is bidding to become the first American man to reach a Slam final since Andy Roddick finished Wimbledon runner-up in 2009.
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The pair will face off for a record 52nd time in their careers in the other men's semifinal on Friday evening.
That was played over on Court 18, which now bears a plaque commemorating the record-setter.
After being kept on the run for six hours and 36 minutes, the longest ever singles semi-final at the All England Club, how the 32-year-old was still standing was anyone's guess.
Rafael Nadal will resume his match on Sunday (NZT). They both serve like demons, and don't return serves particularly well.
There will be plenty of short rallies, service games will be held, sets will go into tie-break, and victory and defeat will depend critically on such things as return of serve and, of course, nerves.
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The roller-coaster match saw Dabrowski and Xu fight off three match points before tying it at 5-5 in the third set.
Two medical time-outs for the big American hinted at a chance for Anderson, and the South African took advantage with a big break and serving out to level up at two sets apiece.
When two tall men, one 6ft 8in and the other taller by two inches, armed with games that are built around their huge commanding serves, face off against each other, the match nearly invariably proceeds along at least some foreseeable lines. Anderson finally came through on his sixth to lead 25-24, then served out the victory when Isner sailed a forehand wide. Anderson won the opening set before Isner bounced back to take the next two.
Having once again swapped breaks early on in the fourth set, Anderson broke Isner for the third time, and took the match into a decider on his fourth set point.
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