It took Djokovic and Nadal - who were to be the eventual champions - to stop him in the Roland Garros semi-finals in 2016 and 2017.
Alexander Zverev could not hide his frustration after injury left him at the mercy of Austrian Dominic Thiem on Tuesday in his first Grand Slam quarter-final at Roland Garros.
Djokovic continued his solid progress too as he powered to a 6-2, 6-4, 6-2 win over Spain's Fernando Verdasco, and the Serb says he knows Cecchiato quite well.
Play was suspended due to fading light, with Russian Daria Kasatkina leading 7-6 (5) 3-3 against second-seeded Caroline Wozniacki.
Thiem, the Austrian seventh seed, goes on to face either 2016 champion and 12-time major victor Novak Djokovic or Italy's world number 72 Marco Cecchinato for a place in Sunday's final.
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The "big four" of Rafael Nadal, Roger Federer, Novak Djokovic and Andy Murray have dominated for Majors and Masters scene for close to 15 years.
"I was playing very, very well in the beginning, had a great start", Thiem said.
He then needed four sets to overcome the talented Greek teenager Stefanos Tsitsipas and also dropped a set against Italy's Matteo Berrettini, winning 6-3 6-7 6-2 6-3. Meanwhile, Serena Williams and Venus Williams were bagelled in the deciding set as they were dumped out of the women's doubles at the French Open yesterday by third seeds Andreja Klepac and Maria Jose Martinez Sanchez.
Cecchinato is the lowest-ranked French Open semifinalist in 19 years and the first Italian man to make it that far at any major in 40 years. No. 10 seed Sloane Stephens awaits the victor in the quarterfinals after downing Anett Kontaveit 6-2, 6-0.
The 23-year-old will next face U.S. Open runner-up Madison Keys.
The Austrian routed a sluggish Kei Nishikori early, then hung for a 6-2, 6-0, 5-7, 6-4 win.
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Zverev managed just four winners in the second set.
"At the end I was nervous".
"I have practiced with him many times in Monte-Carlo when he was part of the Ricardo Piatti Academy team, and he trained a lot where I live".
After looking down and out for much of the third set, second seed Zverev was sacked up by a code violation for being coached from the stands by his father Alexander Sr midway through the fourth set and he vented his anger by instantly breaking for a 4-2 lead.
American 13th seed Madison Keys also reached her first Roland Garros quarter-final with a 6-1, 6-4 win over Romania's Mihaela Buzarnescu.Keys, the US Open runner-up to Stephens a year ago, will face Kazakhstan's Yulia Putintseva for a place in the semi-finals, after the world number 98 saw off Barbora Strycova 6-4, 6-3. I couldn't serve. I couldn't really do anything.
"Actually I felt good today".
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Rose made just 10 appearances in the Premier League last term, but still impressed Southgate enough to get his name in the final 23.