Dozens of Israeli missiles hit a radar station, Syrian air defense positions and an ammunition dump, Syrian state media said, underscoring the risks of a wider escalation involving Iran and its regional allies.
He said they targeted intelligence, logistics, storage and vehicles as well as the origin of the rockets.
The late-night incident followed a surge in tensions between Israel and Syria, where Iranian and Lebanese Hezbollah forces have been helping Damascus beat back a 7-year-old rebellion.
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On 8 April, Israeli missiles are alleged to have hit an airbase in Homs province - reportedly serving as an Iranian drone command centre and containing an advanced Iranian air defence system - killing seven Iranian personnel.
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The Israeli military said its Iron Dome rocket defence system intercepted some of the incoming projectiles, while others caused only minimal damage.
Israel has vowed to prevent Iran from entrenching itself there and has targeted, or is believed to have targeted, Iranian assets and positions, increasingly in recent months. "The Syrian regime will be held accountable for everything happening in its territory". The IDF Spokesperson's Unit told Israel's Channel 10 News that more than 50 targets were hit in the strike.
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The Guardian reports that Israel is determined not to "permit Tehran to establish a permanent military presence in Syria, accusing Iran of moving drones and missiles into its Arab neighbour".
As that war winds down, and Assad appears to be headed toward victory, Israel fears that Iran, along with tens of thousands of Iranian-backed Shiite militiamen, will carry out attacks against Israel.
However Israel and Russian Federation have maintained shut communications to forestall their air forces from coming into battle.
Tensions have been high since US President Donald Trump announced he was quitting the Iranian nuclear deal on Tuesday, prompting Israel to go on high alert.
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Any confrontation between Iran and Israel is likely to play out first and foremost on the battlefields of Syria, where Iran has built an extensive network of militias during Syria's civil war. The government ordered public to open anti-aircraft shelters in Golan Heights, while mobilizing reservists to reinforce defence of frontiers.