It was at Old Trafford that Wenger helped Arsenal win a league double in 2002 and at this very ground he was sent off once for kicking a water bottler; "The Theatre of Dreams" has indeed been theatrical for the long-serving Gunners' boss.
When Wenger stepped out of the visitors' dugout minutes before kickoff, he was greeted by a thorough, warm round of applause from Manchester United fans. Mourinho's behaviour has been appalling, not just with Wenger but with everyone, particularly Wenger. I say goodbye to everyone.
The loss means Wenger will set an unwanted record before he leaves, with the Gunners now on their worst run of form on the road since England won the World Cup in 1966.
Alex Iwobi also starts on the wing, as does Granit Xhaka in the middle of the park, and there is a return to Old Trafford for Henrikh Mkhitaryan, who passed a late fitness test to make the line-up. It is great testament to his talent, professionalism and determination that he has been able to dedicate 22 years of his life to a job that he loves.
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'I would say that until 2004 because then there was a power change but for about a decade was about Arsenal versus United'. He's been Arsenal manager and that's it.
"He deserves the respect that I know we will show show him today".
"I am pleased that he has announced he is leaving at this stage of the season, as he can now have the send-off that he truly deserves".
Arsenal haven't got their hands on the Premier League title since 2003-04 when Wenger's side famously finished the campaign unbeaten. This gives Manchester United a big advantage, along with a good chance to add some cushion to the 2nd place aspirations.
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Arsenal, meanwhile, have made a host of changes, ahead of their clash Atletico Madrid in the second leg of the Europa League semi-final this week. And they made sure Wenger felt their appreciation.
Mourinho also stated that Wenger made him a better coach and that he does not believe that Wenger will retire anytime soon, "I am going to remember Arsene as a big opponent, the manager of the Invincibles". But the pregame moment was special, and well engineered by United.
Konstantinos Mavropanos has been handed a surprise Arsenal debut ahead of the Premier League game against Manchester United at Old Trafford.
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