Amtrak Train 91 was carrying about 139 passengers and eight crew members when it collided with the CSX freight train at around 2:35 a.m. ET Sunday, Amtrak said in a statement released after the crash.
The Amtrak train had seven passenger cars and one locomotive, while the CSX train had two locomotives and 34 empty autorack cars.
A police spokesman said the injuries ranged from "scratches to more severe broken bones" but could not say whether any were life-threatening.
"Passengers who were not transported to local area hospitals with injuries were transported to a nearby shelter", Lexington County said in a later statement.
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The Lexington County Sheriff's Department tweeted that the collision and derailment occurred near Charleston Highway and Pine Ridge Road.
President Donald Trump is leading a group of people across the nation who are expressing grief over the train collision in SC that's left two people dead.
Officials also say roughly 5,000 gallons of fuel had spilled as a result of the crash, it is now being cleaned up.
National Transportation Safety Board investigators were on their way to the crash site, about 10 miles south of Columbia.
Five seconds before the crash, the train's brakes were applied.
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Image: Emergency services at the scene in Cayce, South Carolina.
Last week, a train carrying dozens of Republican members of congress collided with a truck in West Virginia.
It is not known how many people were travelling on the goods train, or whether one of the two trains was stationary at the time of the collision.
It is the third deadly wreck involving Amtrak in less than two months. The truck driver was killed and six people were injured in the incident.
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