The 40-year-old forward, who made his debut for the Giallorossi in 1993, announced on Thursday that this would be the final fixture of a Roma career in which he has won one Scudetto and two Coppa Italias with his boyhood club.
A big win for Roma, and fantastic that Totti's last appearance saw a positive result to help the club finish as runners-up to Juventus.
Totti has not hidden his hard relationship with Roma coach Luciano Spalletti, who has used Totti mainly as a last-option substitute.
You want to keep dreaming, you try to slip back into the dream but you never can.
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With a friendship of 15 years preceding their courtship and eventual engagement, the two have known each other nearly their whole lives.
A signed ball kicked into the south curve of the stadium preceded a farewell speech in which Totti said that "unfortunately this moment has come, and I hoped it never would".
The reception he received at the Stadio Olimpico, and the farewell from the whole city of Rome and Italian football is one to remember forever. I will no longer entertain you with my feet, but my heart will always be there with you.
"After 16 years, I will go into the dressing-room and he won't be sitting in the same place". Forgive me for not giving interviews and clarifying my thoughts, but it's not easy to turn out the light.
But I still hated this footballer called Totti and weirdly, it was for none of all the above. This time, I can't see what the future looks like through the holes of the net. "I'm ready for a new challenge".
"It is impossible to sum up 28 years in a few sentences", Totti said.
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Neither expects that to be the case, but they are realistic and understand the inevitable is coming sooner rather than later. Fort and Al Unser Sr.as the only four-time race winners. "It has benefited us in terms of the buzz".
And Roma finally got in front with 16 minutes remaining, with Strootman finding Dzeko, whose impressive cut-back set up De Rossi to fire in left-footed and delight the home crowd.
Yet for Totti, and the thousands of fans who showed up sporting special T-shirts and banners to pay tribute to "Il Re di Roma" (The King of Rome), it was a nervy final game of the season.
But, let's finish on Totti, who is absolutely everything to Roma.
Totti has appeared in 785 matches in all competitions with Roma, third all-time in Italy for most games with a single club behind only Maldini (902 with AC Milan) and Javier Zanetti (858 with Inter Milan).
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